--- a/setup.py
+++ b/setup.py
@@ -543,7 +543,8 @@ class PyBuildExt(build_ext):
                         add_dir_to_list(dir_list, directory)
 
         if os.path.normpath(sys.prefix) != '/usr' \
-                and not sysconfig.get_config_var('PYTHONFRAMEWORK'):
+                and not sysconfig.get_config_var('PYTHONFRAMEWORK') \
+                and not cross_compiling:
             # OSX note: Don't add LIBDIR and INCLUDEDIR to building a framework
             # (PYTHONFRAMEWORK is set) to avoid # linking problems when
             # building a framework with different architectures than
